42,43 Low levels of CoQ 10 have been related to the higher oxidative stress during aging, and in different related diseases.
Supplementation with CoQ 10 does not increase tissue levels above normal (except in liver and spleen) in young and healthy individuals, but in older animals, with decreased CoQ 10, supplemental CoQ 10 can restore normal levels. For example, old rats have increased levels of CoQ 10 in mitochondria from the brain 40 but lower levels in mitochondria from skeletal muscle, 41so it would be important to determine whether these tissue-dependent changes are related to a loss of function or antioxidant capability. 39 However, the changes in CoQ 10 levels during aging are tissue- and organ-dependent. 35–37 In addition to a decrease in its biosynthesis, other factors or situations may affect the levels or functions of CoQ 10, including an increase in degradation 38 or changes in membrane lipids which prevent the movement of this quinone – as occurs in different age-related diseases. 34 The CoQ 10 levels increase in the first 20 years of life however, the organism begins to lose its ability to synthesize CoQ 10 during aging, and the coenzyme becomes deficient.
Jose Lopez-Miranda, in Aging, 2014 CoQ 10 and AgingĬoQ 10 is synthesized in all cells in healthy individuals. More recently studies with less than 55 patients receiving optimal heart failure therapy showed no differences.Įlena M. There was no difference in survival between the two groups. The enzyme group had fewer patients with pulmonary edema, 20 versus 51, and cardiac asthma, 97 versus 198 ( p < 0.001). (From Raj, S.R., Weisel, R.D., and Verma, S. CAD Coronary artery disease CHF Congestive heart failure CO Cardiac output DCM Nonischemic dilated cardiomyopathy echo Echocardiography EF Ejection fraction FS Fractional shortening IC Impedance cardiograph LV Left ventricular MUGA Gated radionuclide assessment n Number of patients N/A Not available NYHA New York Heart Association QOL Quality of life SV stroke volume Xover Cross-over.